Correction: Computational Model Explains High Activity and Rapid Cycling of Rho GTPases within Protein Complexes

نویسندگان

  • Andrew B. Goryachev
  • Alexandra V. Pokhilko
چکیده

dðRDÞ=dt 1⁄4 k81RDA k18RD A þ k31RDE k13RD E k19RD þ k91R D þ k21RT k12RD M dðRTÞ=dt 1⁄4 k52RT E k25RT E þ k92R T k29RT k21RT þ k62RTA k26RT A k2MRT E þ kM2M þ k12RD M dðRDEÞ=dt 1⁄4 k13RD E k31RDE þ k43RE D k34RDE þ k53RTE dðREÞ=dt 1⁄4 k34RDE k43RE D þ k54RTE k45RE T þ k94R E k49RE dðRT EÞ=dt 1⁄4 k45RE T k54RTE þ k25RT E k52RTE k53RTE dðRT AÞ=dt 1⁄4 k26RT A k62RTA k68RTA þ k76RA T k67RTA dðRAÞ=dt 1⁄4 k67RTA k76RA T þ k97R A k79RA þ k87RDA k78RA D dðRDAÞ=dt 1⁄4 k68RT A þ k78RA D k87RDA þ k18RD A k81RDA dðRÞ=dt 1⁄4 k29RT k92R T þ k49RE k94R E þ k19RD k91R D þ k79RA k97R A dðEÞ=dt 1⁄4 k31RDE k13RD E þ k52RTE k25RT E þ k49RE k94R E k2MRT E þ kM2M dðAÞ=dt 1⁄4 k81RDA k18RD A þ k62RTA k26RT A þ k79RA k97R A dðMÞ=dt 1⁄4 k2MRT E kM2M

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Computational Model Explains High Activity and Rapid Cycling of Rho GTPases within Protein Complexes

Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster than they would spontaneously cycle in vitro. At the same time, experiments report concomitant excess of the activated, GTP-bound form of GTPase...

متن کامل

Atypical Mechanism of Regulation of the Wrch-1 Rho Family Small GTPase

Rho family GTPases are GDP/GTP-regulated molecular switches that regulate signaling pathways controlling diverse cellular processes. Wrch-1 was identified as a Wnt-1 regulated Cdc42 homolog, upregulated by Wnt1 signaling in Wnt1-transformed mouse mammary cells, and was able to promote formation of filopodia and activate the PAK serine/threonine kinase. Wrch-1 shares significant sequence and fun...

متن کامل

A built-in arginine finger triggers the self-stimulatory GTPase-activating activity of rho family GTPases.

Signal transduction through the Rho family GTPases requires regulated cycling of the GTPases between the active GTP-bound state and the inactive GDP-bound state. Rho family members containing an arginine residue at position 186 in the C-terminal polybasic region were found to possess a self-stimulatory GTPase-activating protein (GAP) activity through homophilic interaction, resulting in signifi...

متن کامل

Interaction between Rho GTPases and 14-3-3 Proteins

The Rho GTPase family accounts for as many as 20 members. Among them, the archetypes RhoA, Rac1, and Cdc42 have been the most well-characterized. Like all members of the small GTPases superfamily, Rho proteins act as molecular switches to control cellular processes by cycling between active, GTP-bound and inactive, GDP-bound states. The 14-3-3 family proteins comprise seven isoforms. They exist...

متن کامل

RhoGDI: multiple functions in the regulation of Rho family GTPase activities.

RhoGDI (Rho GDP-dissociation inhibitor) was identified as a down-regulator of Rho family GTPases typified by its ability to prevent nucleotide exchange and membrane association. Structural studies on GTPase-RhoGDI complexes, in combination with biochemical and cell biological results, have provided insight as to how RhoGDI exerts its effects on nucleotide binding, the membrane association-disso...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • PLoS Computational Biology

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2007